Therapeutic Activity of Phyto Ligands from Honey and Standard Drugs against Staphylococcus aureus PBP2a (5M19)

Staphylococcus aureus is the most dangerous of all many common staphylococcal bacteria. These gram-positive, sphere-shaped (coccal) bacteria often cause skin infections but can pneumonia, heart valve infections, and bone may be resistant to treatment with some antibiotics. Phenols were abundant phytochemical compounds accounted for 25.8% composition honey. The presence these phytochemicals implied that honey could have therapeutic properties like antimicrobial, anticancer, antioxidant, diuretic, anti-inflammatory activities. two out six tested faulted Lipinski rule 5 which states Hydrogen Bond Donor (HBD) < –Bond Acceptor (HBA) , 10 Molecular Weight 500 weight, H-bond donors, <10 acceptors.< number rotatable bonds, 140 Å2 PSA value In this study. favourable overall docking score was observed in range -3.085 -8.724. Chlorogenic acid had best docked (lowest binding energy)when compared synthetic inhibitors other phytoligands. manners geometrical orientation studied phyto ligand from Honey standard drugs against PBP2a (5M19). results revealed that, showed pivotal interactions PBP2a, as it exhibited energy (-8.724 kcal/mol) (Cefoxitin; -5.985 kcal/mol, Oxacillin; -5.222 kcal/mol methiclin -3.08 phytoligands (protocatechuic -4.473 Hesperetin -4.191 tested. Hence, promising lead candidates acting allosteric effectors might subjecte d further structural optimization enhance their biological activity hence been synthesized evaluate actual activity.